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The reviewer RD declared a shared parent affiliation with the author ISG to the handling editor at the time of review

[42] However, one should note that glutathione mainly affects the melanin indices and ultraviolet spots in the sun-exposed areas

For example, berberine, often called natures Ozempic, has been shown to improve insulin sensitivity, reduce blood sugar levels, and potentially promote mild weight loss by activating an enzyme called AMPK, which regulates metabolism and energy use

The need of the hour is to have more randomized, double-blind, placebo-controlled trials with a larger sample size, long term follow-up period, with well defined primary and secondary outcomes, targeted to evaluate the efficacy and safety of the skin-lightening effects of topical, oral and parenteral glutathione