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Prospective studies, such as the UK Prospective Diabetes Study (UKPDS) demonstrated that T2D is a progressive disease that worsens over time, whatever the pharmacological management used to reduce daily glucose excursion

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Anti-inflammatory cytokines regulate mature neurogenesis in response to immune activation, while the neurovascular system controls the neural stem cell niche (Vallon and Chang 2014)

Direct indexing is an investment strategy that allows investors to directly own the individual securities that make up an indexjust like the S&P 500rather than having to invest in a fund that tracks an index