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1 Introduction Discovered 30 years ago, the dopamine D 4 receptor (D 4 R) initially drew attention due to its strong affinity for the atypical antipsychotic clozapine, an affinity found to be significantly higher than for the previously discovered D 1 , D 2 and D 3 receptors (D 1 R, D 2 R and D 3 R) ( 4 R antagonists

Thus, unlike previous in vitro biochemical studies or metabolic engineering efforts, which had excluded arGSTs, we set out to confirm our hypothesis by performing coupled enzymatic reactions with 3,4- cis -leucocyanidin ( 6 ) combining clarified Escherichia coli cell lysates expressing At LDOX and the well-studied arGST Ph AN9 from petunia

PEG incorporation extends circulation, reduces uptake by liver and spleen, and shows no toxicity (Gregoriadis 1995

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