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While our meta-analysis demonstrated robust protective associations between GLP-1R activation and psychiatric conditions such as schizophrenia and anxiety disorders, sensitivity analyses revealed broader CIs that occasionally crossed the null
Phase 2 clinical trial data published in the New England Journal of Medicine (Jastreboff et al., 2023) demonstrated mean body weight reductions of up to approximately 24% over 48 weeks in adults with obesity a notable finding, though long-term durability data and head-to-head comparisons with other treatments are not yet available
Nohigher starting doses increase nausea and side effects without accelerating weight loss
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