All participants in both groups were instructed to adhere to a standardized dietary protocol, beginning with a liquid diet in the first week post-IGB insertion, progressing to a soft diet, and subsequently transitioning to a structured hypocaloric solid diet
In one study, individuals who took semaglutide for 68 weeks lost an average of 14.9% of their body weight, compared to 2.4% in the placebo group
It functions by focusing on appetite hormones, which can be impacted during hormonal shifts in this phase
Gurjar et al (135) revealed that long-acting GLP-1 analogs regulated the expression of myostatin through GLP-1R-mediated PKA and Akt signaling pathways, increasing the expression of the myogenic regulatory factors, MyoD and MyoG, while inhibiting the expression of muscle atrophy-related factors MAFbx and MuRF1, thereby promoting muscle tissue growth and repair, and alleviating muscle atrophy