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Collectively, these findings provide a mechanistic rationale for developing multi-target agonists: GLP-1R appears to provide the most potent and direct anti-MASLD and anti-fibrotic effects in the liver, while GIPR and GCGR offer complementary benefits for glucose and lipid metabolism, with GIPR also exhibiting superior cardiovascular protection
It also protects the kidneys
The NHS notes that adults need only around 1.5 micrograms a day, which a normal mixed diet covers with ease
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