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Therapeutic targeting of ER-associated degradation and ER stress ER-associated degradation and unfolded protein response signaling represent critical targets for alleviating proteotoxic stress in cardiomyocytes

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More specifically, the 10 residue sequence of the cleavage site at the nsp13/14 junction shown in Figure 2A, with the greatest overall similarity to the GPX1 active site sequence, is 100% identical in the 2003 and 2019 SARS coronaviruses (Figure S1)

This study deserves honest context