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Conclusions A high index of suspicion for hyperammonaemia is mandatory in paediatric patients of any age with suggestive clinical symptoms, given that almost all survivors have developmental disabilities that correlate with the number, severity and duration of hyperammonaemic episodes

Theoretical risks Long-term or high-frequency use raises theoretical concerns about copper accumulation

If you have a true history of severe or active pancreatitis, retatrutide is not recommended