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The largest individual exposures in this window include: Mercks pembrolizumab (Keytruda), with $25 billion in 2023 revenue, faces composition of matter patent expiry in 2028, though secondary patents on specific dosing methods, combination regimens, and PD-1 binding domains extend the formal portfolio timeline
Upregulating carnitine palmitoyltransferase 1 attenuates hyperoxia-induced endothelial cell dysfunction and persistent lung injury
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