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Dose selection : Phase 1 data informed the dose range (0.5-12 mg) and escalation schedules used in the subsequent Phase 2 program
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Administration of semaglutide at the dose regimen of ~ 90 g/kg/day failed to evidence significant weight loss but more importantly, led to alteration of cortical bone microarchitecture, represented by lower cortical thickness, and ultimately to a significant decrease in bone strength [69]
Randomized controlled trial comparing hyaluronic acid, platelet-rich plasma and the combination of both in the treatment of mild and moderate osteoarthritis of the knee
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