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Handling Notes: Handle with appropriate laboratory safety equipment Avoid freeze-thaw cycles once reconstituted Use sterile techniques for reconstitution Store in amber vials to protect from light degradation Certificate of Analysis: Available upon request Important: For laboratory research use only

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The excess AGEs could lead to non-enzymatic cross-linking of collagen, break the adhesion of osteoblasts to the extracellular matrix and leads to bone fragility ( / mice are mainly used to study atherosclerosis, but ApoE / mice can also be used to study osteoporosis