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The p53 protein, a key human tumor suppressor, regulates the expression of oncogenes and downstream signaling pathways, contributing to biological effects (7275): Beyond its role in cancer, p53 is highly expressed in the brain, where it influences dendritic growth, oxidative stress response, apoptosis and autophagy, making p53 dysfunction and associated pathways noteworthy in the pathogenesis of AD (7678)

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Therapeutic potential of metformin in papillary thyroid cancer in vitro and in vivo

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Methods We used a subset of Truveta Data to identify patients aged 18 years or older with overweight or obesity (defined as BMI over 27) and at least one medication dispense (i.e., prescription filled at a pharmacy) for a GLP-1 RA between January 2025 and July 2025

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