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Notably, although plant metabolites such as berberine, emodin and curcumin have been shown in vitro to improve NAFLD symptoms by regulating hepatic lipid metabolism and inhibiting hepatocellular inflammation, they are categorized as pan-assay interference compounds (PAINS), which may generate false-positive results in vitro through non-specific mechanisms ( in vivo studies to exclude assay interference

MazzoneAStregePRGibbonsSJAlcainoCJoshiVHaakAJet al

Oxidative stress occurs when there is an imbalance between the amount of free radicals and our ability to fight them off, and increases as we age