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These findings emphasize that targeted antagonism of NMDA receptor signalling lowers body weight independently of MC4R, indicating that this preclinical drug candidate might not only be effective in treating polygenic obesity but also holds potential as an effective weight loss strategy for patients with loss-of-function mutations in MC4R , the most common form of monogenic obesity 32

Dilokthornsakul, W., Dhippayom, T., & Dilokthornsakul, P

But when it comes to prescription medications like semaglutidethe active ingredient in Ozempicmore is not always better, and safety must remain the priority

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