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Dietary Limitations: Many "fad" diets focus on extreme calorie reduction, which can slow metabolism over time and lead to nutrient deficiencies
HK2 interacts with nuclear proteins such as Max, Sirt1, IWS1, CTR9, and Spin1, increasing chromatin accessibility to regulate gene expression
Hum Brain Mapp 2014
CUL3 is linked to the ubiquitin-like protein NEDD8 [156] and represents a scaffolding protein between KEAP1 and RBX1
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