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In the early stage, inflammation leads to the secretion of inflammatory and pro-degradative mediators, including cytokines such as interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor- (TNF-), lipid mediators such as prostaglandin E2 (PGE 2 ), and matrix metalloproteinases (MMPs) by macrophages and fibroblast-like synoviocytes 7,10

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GLP-1s and the Menopause: What you need to know Going through perimenopause and menopause brings significant changes to your body, and many women find themselves struggling with weight gain and metabolic changes theyve never experienced before

For example, losing 5 to 10% of body weight can help lower the risk of heart disease and hypertension