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Research Note: Published preclinical research, including a 2025 literature and patent review in the journal Pharmaceuticals (Jzwiak et al., 2025, Pharmaceuticals ), has documented BPC-157's effects on angiogenesis, nitric oxide signaling, and tissue protection in animal models, though authors note that no completed human clinical trials have been published to confirm these effects in people
It can cause permanent neurological changes or fatigue
doi:10.1016/j.bcp.2018.05.003 Neelakantan H, Brightwell CR, Graber TG, et al