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Compared to DPP4 inhibitor, GLP-1RA use was associated with decreased risks of 30 outcomes, including respiratory failure, pneumonia, anemia, post-thrombotic sequelae, and bacterial infections, and increased risk of 13 outcomes, including sleep disturbances, nausea, vomiting, headaches, hypotension, sleep disturbances, and nephrolithiasis

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Application of liraglutide reduced mitochondrial damage by attenuating mitophagy via the protein phosphatase and tensin homolog-induced kinase 1 (PINK1)/Parkin pathway, the most well-known pathway for mitophagy (Figure 3)

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