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certificate of analysis available on request Research Applications Suitable Laboratory Uses for GLP-1 GLP-1R binding kinetics, receptor occupancy, and displacement assays primary reference ligand cAMP/PKA/CREB signalling cascade studies in pancreatic -cell and islet models PI3K/Akt -cell survival, proliferation, and anti-apoptotic pathway research Glucose-dependent insulin secretion and incretin effect characterisation assays Glucagon suppression and -cell / -cell paracrine signalling pathway studies DPP-4 degradation kinetics and GLP-1(936)amide metabolite pathway research CNS appetite regulation hypothalamic and brainstem GLP-1R circuit studies Dopaminergic reward signalling and hedonic eating pathway investigations Cardiovascular GLP-1R pathway and cardioprotection studies Anti-inflammatory and immune cell GLP-1R signalling research Neuroprotection pathway studies in neuronal cell models Comparative native GLP-1 vs

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and the potential launch or commercialization of any of Companys product candidates or products and our strategic and product development objectives and goals, and the other factors discussed under the caption Risk Factors in our Annual Report on Form 10-K for the year ended December 31, 2024 and Quarterly Report on Form 10-Q for the quarter ended June 30, 2025, filed with the Securities and Exchange Commission on August 12, 2025 and in our other filings with the SEC