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With respect to body weight, a higher baseline body-mass-index is a predictor of absolute weight reduction, albeit with substantial body weight loss even in those with a BMI 50 years with either chronic kidney disease and an eGFR of less than 60 ml/min per 1.73 m 2 or history of congestive heart failure (NY Heart Association Class II or III)
GLP-1 RAs, by addressing both insulin resistance and adiposity, occupy a mechanistically plausible position in this interface
doi:10.1136/gutjnl-2014-308209 45
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