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Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis
The researchers found that the elevated ROS level triggered by erastin can stimulate Nedd4 expression by inducing Forkhead Box M1 (FOXM1), an essential regulator for oxidative stress and cancer cell survival
This process, combined with the increase in lean muscle mass, creates a more efficient metabolic state
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