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A GLP-1 RA should be thought of as an addition to a healthy lifestyle, rather than a replacement

Glucagon-like peptide 1 (GLP-1) controls insulin release from the pancreas, which in turn controls glucose homeostasis

Common gastrointestinal effects may occur, particularly during the first 12 weeks as the gut microbiome adjusts

8 Clinical positioning and pathways: risk-stratified decision matrix 8.1 Bridging gap between evidence and guidelines Traditional stepped care for PCOS-related infertility typically positions lifestyle intervention as the first-line therapy, followed by ovulation induction (OI) with letrozole or clomiphene, and ultimately ART