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While it remains unclear whether KP modulation is directly required for ketamines rapid antidepressant actions, these findings underscore the KPs relevance in NMDAR-mediated excitatory neurotransmission and MDD pathophysiology

One of the most studied mechanisms is the anti-cachectic effects, mediated by protecting the muscle from catabolism

With increasing age, there is a reduction in its endogenous production and the subsequent shrinkage in its elasticity results in skin falling and wrinkle formation

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