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Medical and Editorial Standards Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims

Matek D, Matek I, Staresinic E, Japjec M, Bojanic I, Boban Blagaic A, et al

One very small study found that people who used semaglutide had lower B12 levels, but these patients also had bariatric surgery prior to using semaglutideso its hard to say if using semaglutide would lead to a B12 deficiency, requiring additional B12

Thus, treatment resistant symptoms in major depressive disorder or other mood disorders may potentially be addressed with DSIP [10]