The downstream consequences include enhanced glucose uptake into skeletal muscle independent of insulin, increased fatty acid oxidation, and suppression of inflammatory signaling
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And this point is relevant as TMAO is excreted by the kidneys, and so damaged kidneys cannot excrete TMAO effectively
The Real Connection: Hormones, PCOS, and Indirect Effects Now, this is where the conversation gets more interesting and moves beyond a simple 'yes' or 'no.' While spironolactone doesn't directly burn fat, its hormonal effects can play a supportive, albeit indirect, role for some people, particularly those with PCOS