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For instance, low IGFBP-1 levels with high C-reactive protein values are strong predictors of MetS [252, 253]

GLP-1 RA users were then categorized into 4 study groups at the yearly level based on whether they had a diagnosis code for diabetes or obesity/overweight within 365 days (1 year) of the index date: (1) members who had an International Statistical Classification of Diseases, Tenth Revision diagnosis code for diabetes (E10x, E11x, and E13x) in at least 1 inpatient or outpatient claim and no obesity/overweight diagnosis code (Z682x, Z683x, Z684x, E660x, E663, E669)

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In this context, it is still debated whether inflammation directly causes neurodegeneration or the neuronal loss induces glia activation, generating a positive feedback loop in which inflammatory cytokines and neurotoxic molecules released by activated glial cells promote both neurodegeneration and self-perpetuating inflammatory response (Figure 1B)