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Studies were excluded if they focused on investigational therapies other than semaglutide, compared tirzepatide to combination therapies (e.g., CagriSema) rather than semaglutide directly, or investigated non-clinical outcomes (e.g., gastric motility) without reporting weight or glycemic endpoints
However, the difference in the net absorption was estimated to be smaller (approximately one-tenth) due to much longer transit in the colon than in the small intestine 273,274,275
Maintaining adequate protein intake during weight loss is important for preserving lean muscle mass according to Harvard Health Publishing.
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