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Components of the ER-associated degradation (ERAD) pathwayincluding Syvn1, Sel1l, Derl3, Amfr, and Ubxn4were also reduced, along with genes involved in vesicular trafficking (Sec24a, Sec24c, Sec24d, Sec23b, Sec31a, Sar1a, Sec61a1, Ssr3), suggesting a global decline in secretory activity
Cochrane Database of Systematic Reviews, 11 (11), CD015385
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