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Be alert to symptoms that may indicate thyroid dysfunction , such as: Worsening fatigue, cold intolerance, or constipation (suggesting under-replacement) Palpitations, anxiety, tremor, or heat intolerance (suggesting over-replacement) A lump or swelling in the neck, hoarseness, or difficulty swallowing (which should prompt urgent evaluation according to NICE guideline NG12) [9] [10] Whilst there is no evidence that Wegovy causes thyroid dysfunction in humans , you should report any new or unusual neck symptoms to your GP immediately

What stood out: CagriSema achieved 23.0% weight loss at 84 weeks (efficacy estimand) Tirzepatide achieved 25.5% On the treatment-regimen estimand, weight loss was 20.2% vs 23.6% Primary endpoint not met: CagriSema did not demonstrate non-inferiority vs tirzepatide on weight loss at 84 weeks Why this matters This is a reminder that in obesity pharmacotherapy, very effective and best-in-class are not the same conversation