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Supernatants were filtered over 0.2 m filters and stored at -20C until analysis

Recovery Results Treatment time Aftercare The science of supplements for melasma Glutathione & polypodium extract have the highest number of scientific publications behind them These oral supplements work as potent antioxidants & pigment modulators They may play a marginal role in treating melasma & pigmentation They are best used as adjunctive therapy with topical creams, peels & lasers The recommended glutathione dose is 500 mg daily The recommended polypodium dose is 480 mg twice daily This combination may be effective for skin lightening What two supplements have the greatest effect on pigmentation & melasma