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The NO pathway is especially important in endothelial cells, as PKA activates NO synthase (NOS), which can produce more nitric acid and does result in reduced small intestine, large intestine, and colon motility
Psychological therapies : Cognitive behavioural therapy (CBT) helps patients develop coping strategies, manage pain perception, and address associated anxiety and depression
He also points to intense side effects such as nausea, diarrhea, constipation, and vomiting as a reason for stopping
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