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Not because of safety concerns per se, but because it becomes impossible to know whats actually working
Elimination occurs primarily through renal clearance, with a plasma half-life of approximately 2-4 hours in rodent models
To determine the expression level of chondrogenesis-related genes aggrecan ( Acan ) and Col-2 , cells were collected after 7 and 14 days of chondrogenic induction and RT-qPCR was performed
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