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Importantly, the FDA label for Zepbound notes that it can reduce the effectiveness of oral contraceptives, so additional contraceptive methods should be used for 4 weeks after initiation and with each dose increase

While generally safe for healthy individuals, certain populationsincluding immunocompromised patients and premature infantsface elevated risks

Weibull distribution modeling characterized failure patterns of time-to-onset data, where the shape parameter () defined three scenarios: the upper limit of 95% confidence interval (CI) of 1 (wear-out failure: risk escalation with prolonged use) 22 (Table S4)