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People were fighting back and forth about this for a long time, until TECOS, the trial with sitagliptin which was the largest and the best of those trials came out with a completely flat result: there was neither an increase nor a decrease in cardiovascular risk

Kidney function tests , including serum creatinine, estimated glomerular filtration rate (eGFR), and urine albumin-to-creatinine ratio (UACR), warrant attention

The relationship between constipation and UTIs is particularly relevant for women, who already face higher baseline UTI risk due to anatomical factors