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We also provide an update on the targets and clinical prospects of different antioxidants (melatonin, N-acetylcysteine, vitamins, -lipoic acid, mineral elements, phytochemicals, nutritional antioxidants, cytoprotectants and synthetic compounds) in the treatment of CIPN with the help of preclinical and clinical studies, emphasizing the great potential of antioxidants as adjuvant strategies to mitigate CIPN
Modern clinical research has confirmed their general safety when used in appropriate dosages
It facilitates movement of acetyl-CoA into the matrices of mammalian mitochondria during the oxidation of fatty acids
Two patterns are worth calling out because they are predictable rather than alarming
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