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Positive effects observed in studies include: Reduced liver fat accumulation Lower ALT and AST levels in patients with fatty liver Improved insulin sensitivity, which reduces liver workload Decreased inflammation markers Research published in The Lancet found that semaglutide significantly reduced liver fat and improved fibrosis markers in patients with metabolic dysfunction-associated steatohepatitis (MASH)

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They showed that 4-HNE, MDA, and NO2/NO3 ratio (nitrite/nitrate) levels significantly decreased in the PLC-treated group when compared with the placebo group.[ , ] Anthropometric indices In all nine articles that measured BMI,[ , , , , , , , , ] in three articles that measured WHR,[ , , ] in two articles that measured body fat,[ , ] and in all three articles that measured body weight,[ , , ] there was no significant decrease after L-carnitine treatment when compared with the placebo group, but Liang et al