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DSIP Research Applications DSIP is studied in sleep physiology and chronobiology research, including delta-wave sleep architecture, hypothalamic-pituitary-axis interactions, cortisol and ACTH modulation, opioid receptor pathway research, and free-radical scavenging activity

Importantly, these medications carry a boxed warning for risk of thyroid C-cell tumors and are contraindicated in patients with personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

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