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GLP-1 And Pancreatic Cancer Older research pointed to a possible connection between GLP-1 drugs and pancreatic cancer
Glutamate is generated by extra- and intracellular glutaminases Glutaminolysis as illustrated in Figure 2 is associated with the increased expression of both the extrinsic cell membrane phosphate independent glutaminase/gamma glutamyltransferase/gamma glutamyltranspeptidase (PIG, GGT, GGTP) which generates extracellular glutamate [2,12] and intracellular phosphate dependent glutaminases, Phosphate dependent glutaminases (PDG,GLS1 and GAC, [13,14]) which generates glutamate cytosolically [2,13]
Some GLP-1 medications (specifically liraglutide, semaglutide and dulaglutide) have demonstrated cardiovascular benefits in certain patient populations with type 2 diabetes
& Venter, W
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