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Since the discovery and functional verification of GLP-1 in the 1980s ( However, the therapeutic utility of native GLP-1 was limited by its rapid enzymatic degradation and short plasma half-life, which prompted the development of longer-acting receptor agonists

May 12 (UPI) -- U.S

2019: The only oral GLP-1 RA, a semaglutide marketed under the brand name Rybelsus, is approved by the FDA

Studies using fluorescently labeled compounds have found that semaglutide reaches discrete brain regions not through general blood-brain barrier penetration but through circumventricular organs, specialized structures where the barrier is naturally leaky