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LTF can also be synthesized by pro-inflammatory activated microglia (Fillebeen et al., 2001), and may also be related to the iron disturbances in the AD brain with senescent iron-accumulating microglia and lipid-rich microglia (Zeineh et al., 2015
PMID 17522590
It differs from native IGF-1 by having an arginine substitution at the third amino acid (R3) and an additional 13 amino acids at the N-terminus, making it significantly more potent in receptor activation studies
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