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If pancreatitis is suspected (severe persistent upper abdominal pain, sometimes radiating to the back, with or without vomiting), stop taking semaglutide and seek urgent medical advice
Hypersensitivity to Similar Medications: If you have had adverse reactions to other GLP-1 receptor agonists, semaglutide may not be safe for you
That does not mean every study will show the same pattern, but it does explain why dose escalation and tolerability are often discussed together
P for trend = 0.919), and no difference in the effect of tirzepatide on worsening HF or worsening HF excluding oral diuretic intensifications, compared with placebo (Table 2)
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