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The controversy of sKlotho as a biomarker in clinical nephrology As a kidney protective protein, sKlotho deficiency is observed to be associated with reduced kidney function, CKD stages, adverse outcomes, and CKD-MBD, indicating a potential role as a biomarker in CKD

Although lactylation modifications have been demonstrated to regulate ferroptosis across diverse experimental models, it remains unclear whether these mechanisms are restricted to the specific disease contexts and models studied or can be universally extended to all cellular systems