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Low-fat areas such as the inner thigh, the lower abdomen in leaner individuals, and sites near bony prominences should be avoided where possible as they offer less tissue cushioning and produce more pronounced discomfort

These effects are very notable when the peptides are gave before bed, as they can enhance the natural nocturnal GH surge that occurs during deep sleep

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The CNS GLP- 1 receptors are not necessary for the physiological regulation of blood glucose levels by endogenous GLP- 1 or the pharmacological control of glucose homeostasis that depends on GLP- 1 receptors, although further research is needed to investigate the possible role of GLP- 1 receptors expressed outside the beta cell, including within the enteric and peripheral nervous systems, in improving beta cell function through enteral glucose mediation [70, 84]