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There are no scheduled follow-ups, no monthly questionnaires, and no required check-ins, which works for patients who want to stay on a stable dose but may bother anyone who wants closer monitoring

Starting at the lowest dose and increasing slowly over months, rather than rushing to the target dose, dramatically reduces gastrointestinal side effects and improves long-term tolerability

Algunos medicamentos tienen advertencias especficas (boxed warning) sobre riesgo de carcinoma medular de tiroides y sndrome de neoplasia endocrina mltiple tipo 2 (consultar la informacin de prescripcin especfica de cada frmaco)

Allocation was generated centrally using computerised randomisation