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Eric Topol, MD, this is a fabulous review and thanks for bringing this others attention

Weeks 12 are calibration, not peak performance

Additionally, a randomized, double-blind, placebo-controlled trial in 2,588 healthy older adults with mild hyperhomocysteinemia found that daily supplementation with 500 g of vitamin B 12 and 400 g of folic acid for two years reduced blood homocysteine concentrations but had no benefit on depressive symptoms in those with or without depressive symptoms at baseline (110)

And then there's the way semaglutide seems work in the brain's reward system to suppress some "highly motivated" behaviors, like cigarette smoking