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BPC-157 is notably stable in the gastric environment in preclinical models reportedly remaining intact in human gastric juice for extended periods which is one reason it has been studied so extensively in gut-related research

BPC-157 is a 15-amino-acid synthetic peptide derived from a protective protein found in human gastric juice

Many pharmaceutical companies have tried to develop drugs that target Mcl-1, but this has been difficult because the interaction between Mcl-1 and its target protein occurs in a long stretch of 20 to 25 amino acids, which is difficult to block with the small molecules typically used as drugs

Curr Pharm Des 20:11211125 Shibuya M (2011) Vascular endothelial growth factor (VEGF) and its receptor (VEGFR) signaling in angiogenesis: a crucial target for anti- and pro-angiogenic therapies