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Glutathione is thought to brighten skin in two linked ways: by inhibiting tyrosinase (the key enzyme in pigment production) and by shifting melanin synthesis from darker eumelanin toward lighter pheomelanin
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Vitamin B 12 deficiency can develop with heavy regular use of nitrous oxide N 2 O, also known as "laughing gas", used for anaesthesia in a clinical setting or as a propellant gas, commonly abused as a recreational drug
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