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141 They remain in the body, interacting with GLP-1 receptors in various organs, which could lead to DDIs through mechanisms of action such as slowing gastric emptying, reducing fat mass and inflammation, and increasing glomerular filtration rate (GFR) and renal plasma flow, consequently altering the pharmacokinetics of the victim drug (Figure 3)

Another 2024 study, involving more than 400,000 patients in the Netherlands, found that people with Type 2 diabetes who used semaglutide had more than double the risk of developing NAION compared to those who didnt take the drug

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Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway