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While standard therapies, such as glucocorticoids, beta-2 adrenergic receptor (2AR) agonists, and biologics (e.g., anti-IgE, anti-IL-5, anti-IL5R, anti-IL4R) are effective in T2 high asthma, their efficacy is often diminished or non-existent in T2 low or metabolically driven asthma phenotypes
After initial repletion, a maintenance dose is given, often 1,000 mcg intramuscularly every month or every 2 to 3 months, to prevent recurrence of deficiency
I have gained 20 lbs in one year
In mice with asthma, increasing glutathione with NAC lowered inflammation and improved the symptoms [61]
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