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The brand-name pill Rybelsus - which is FDA-approved for type 2 diabetes - uses a compound called SNAC that temporarily neutralizes local stomach acid to allow absorption
Currently undergoing clinical trials is retatrutide, a triple agonist of the GLP-1, GIP and glucagon receptors, which has produced weight loss of 24% 30
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Several clinical studies have shown that bilateral DBS of both targets improves PD symptoms, but postoperative stimulation-induced adverse effects, as well as psychiatric and cognitive effects, are more common with STN DBS
This supply-demand issue has led to poor accessibility and high costs
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